Tokushima's pioneer venture business ranks No. 1 in Japan for production of intravenous transfusion products One of the Otsuka Pharmaceutical Group's nucleus enterprises is well regarded and known within and without the prefecture as the Otsuka of intravenous liquids. The company is an international leader, recognized for research, development, and manufacturing of intravenous liquids as well as medical liquids used in injections, and for plastic containers. A few projects based on sodium chloride obtained in the salt fields of Naruto include the development of new medicines and the redesign of containers and intravenous liquid-related systems. The company plays an active role in the international medical community, holding about 45% of the national market share for the manufacturing of intravenous liquids. Some products produced by the company include Oronine H Ointment and Oronamin-C. Since the Japanese-language word processing software series "Ichitaro" was first released in 1985, over 17 million copies have been sold. Nationally, it has become a household name in computer software. In recent years, most elementary schools have begun to use computers in classes. The company's "Ichitaro Smile" educational support software, designed for elementary students, is used in 15,000 elementary schools around the country, capturing the No. 1 share in Japan. With a focus on cathode ray tubes, fluorescent lights, and X-ray intensifying screens, Nichia develops and markets precision chemical products. The company became internationally famous in 1993 in the nitride semiconductor field for making the world's first blue LED. Expectations center on the next generation of energy-saving inventions such as DVDs with an increased capacity to store information and the simultaneous creation of nitride and white LEDs has greatly enlarged the company's range applications. Its innovative technology has kept it in the international spotlight. The Shikoku Kakoki Company builds product packaging machines that make the container and then fill it with a variety of liquid foods of various consistencies, such as milk, yogurt, juice, soup, and Japanese sake. Their production of milk-carton-type paper containers accounts for over 60% of the domestic market share. While developing a variety of sterilization methods and ways to extend the shelf life of food, the Shikoku Kakoki Company is also well-known as a top-class producer of the "Sato no Yuki" brand of tofu products. This company, which started out as a producer of information-related paper products, has spent many years developing purification technology and has begun refining Stevia. From the plant extract to the processed enzyme, Nippon Paper Chemicals uses proprietary patented technology to add value to its products, which account for roughly 35% of the national market share, making it the No. 1 producer of Stevia in Japan. With a sweetness 200 times that of sugar making it low in absorbed calories, Stevia has a variety of commercial uses, from juice and sweets, to pickles and processed foods. The company supplies bearings for use in a wide variety of fields, from domestic to high-tech, ranging from machinery to automobiles, including domestic electrical appliances. Bearings manufactured by the company are used in the rotating parts of automobiles, from engines to wheels. Cars contain from 60 to 100 bearing systems, and Koyo Seiko manufactures all the bearings required for these rotating parts. Koyo Seiko is a world leader in its field, holding approximately 60% of the national market share and 20% of the global market share for the water pump bearings used in car engine fans.